Enantiospecific Pharmacogenomics of Fluvastatin
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چکیده
منابع مشابه
Enantiospecific synthesis of pacifigorgianes
Pacifigorgianes 1 are a small group of sesquiterpenes, containing bicyclo[4.3.0]nonane moiety, found to be present in both marine and terrestrial sources. The first member of this group, ichthyotoxic (+)pacifigorgiol 2 was isolated in 1982 by the research groups of Fenical and Clardy 1 from the pacific gorgonian coral Pacifigorgia cf. adamssi. Later in 1986, Simpa and coworkers 2 reported the i...
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Enantioenriched secondary and tertiary alkyl pinacolboronic esters undergo enantiospecific deborylative alkynylation through a Zweifel-type alkenylation followed by a 1,2-elimination reaction. The process involves use of α-lithio vinyl bromide or vinyl carbamate species, for which application to Zweifel-type reactions has not previously been explored. The resulting functionalized 1,1-disubstitu...
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Two convenient methodologies have beendescribed for the enantiospecific synthesis of (–)-valeranone 1. The hydrindanone 12, obtained from the readily andabundantly available monoterpene (R)-carvone,has been converted into the ketoaldehyde 16via the alkene 15b. In anotherdirection the lactone 18, obtainedfrom the hydrindanone 12, has beenelaborated into the ketoaldehyde 16employing two methodolo...
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Pharmacogenomics, a revolutionary chapter in the history of pharmacology, has received new impetus from the development and accessibility of molecular biotechnologies, notably DNA chips. The longstanding notion of responders/non-responders has given way to a more organic approach, where idiosyncrasy becomes an obsolete concept. This is a major step towards predictive, individualized medicine. I...
متن کاملEnantiospecific formal total synthesis of (+)-fawcettimine.
The diastereospecific attack of the silyl enol ether on the activated cyclopropyl diester 27 generated the hydrindanone 28 with complete stereocontrol. Thermal decarbomethoxylation of 28 gave the monoester 29, a key intermediate in Heathcock's synthesis, thereby completing a formal total synthesis of (+)-fawcettimine 1. The analogous cyclization of 33, the diastereomer of 27, afforded the diast...
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ژورنال
عنوان ژورنال: Clinical Pharmacology & Therapeutics
سال: 2019
ISSN: 0009-9236,1532-6535
DOI: 10.1002/cpt.1463